Human OA Peripheral Blood Mononuclear Cells

Description

Human OA Peripheral Blood Mononuclear Cells (hOA-PBMCs) are mainly isolated from the peripheral blood of patients with osteoarthritis (OA), including T cells, B cells, NK cells and monocytes. Peripheral blood from osteoarthritis (OA) patients.[1]. Morphologically, hOA-PBMCs are round or macrophage-like. PBMCs play an important role in immune regulation, inflammatory response and antigen presentation [2-3]. Round or macrophage-like morphology; mononuclear cells; mostly suspension growth typical of PBMCsIn the context of OA disease, PBMCs may participate in the chronic low-grade inflammatory process, exacerbating articular cartilage degradation and synovial inflammation by secreting proinflammatory cytokines (such as TNF-α, IL-1β, IL-6)Elevated expression of proinflammatory cytokines TNF-α, IL-1β, IL-6 in the OA context .Participate in chronic low-grade inflammation contributing to cartilage degradation and synovial inflammation in OA