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Primary Cells

Human Pancreatic Microvascular Endothelial Cells

  • For research use only

Cat No.

ABC-TC3745
Product Type

Pancreatic Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Storage

Liquid Nitrogen

Human Pancreatic Microvascular Endothelial Cells support studies on islet vascularization, angiogenesis, and diabetes-related microvascular complications.

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  • Human Pancreatic Microvascular Endothelial Cells
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Microvascular Endothelial Cells

Description

Human Pancreatic Microvascular Endothelial Cells (HPMECs) are primary cells isolated from microvessels within human pancreatic tissue. They exhibit classic cobblestone morphology and form tight monolayers in culture, demonstrating functional barrier properties. They express endothelial markers CD31(PECAM-1) and von Willebrand factor (vWF), while being negative for fibroblast markers such as FSP-1. These cells closely reflect the native islet endothelium, engaging in angiocrine signaling that supports β-cell survival, insulin secretion, and islet vascular plasticity. Functionally, HPMECs respond to VEGF-A and VEGF-C, and participate in capillary-like tube formation. As finite-life primary cells, they are not suitable for long-term passaging. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Human Pancreatic Microvascular Endothelial Cells, Pancreatic MVECs Human, HPMVECs, Pancreas Microvascular ECs, Human Pancreatic Endothelial Cells
Species

Human
Cat.No

ABC-TC3745
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • HPMECs are an ideal model for studying pancreatic microvascular biology and pathology, their primary application includes investigation into angiogenesis, endothelial-β cell crosstalk, vascular permeability, and drug screening. They are widely used to explore islet vascular adaptation in diabetes and to evaluate therapeutic strategies targeting angiocrine factors such as VEGF-A and HGF. Their utility spans functional assays like tube formation, barrier integrity, cytokine response, and co-culture systems with pancreatic islets.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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