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Primary Cells

Human Parathyroid Cells

  • For research use only

Cat No.

ABC-TC110L
Product Type

Parathyroid Cells
Cell Type

Parathyroid Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Parathyroid
Disease

Normal
Storage

Liquid Nitrogen

Human parathyroid cells produce PTH, key in calcium balance; linked to parathyroid disorders; cryopreserved with careful freeze-thaw handling.

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  • Human Parathyroid Cells
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Parathyroid Cells

Description

Human Parathyroid Cells are primary endocrine cells isolated from normal adult human parathyroid gland tissue and cryopreserved after primary culture. These polygonal cells, mainly chief cells, possess abundant cytoplasm and central nuclei. They synthesize and secrete parathyroid hormone (PTH), which regulates calcium and phosphate homeostasis. Key markers include calcium-sensing receptor (CaSR), PTH, and chromogranin A. Parathyroid cell dysfunction or hyperplasia is linked to disorders such as hyperparathyroidism and hypoparathyroidism. In vitro, these cells maintain hormone secretion in response to extracellular calcium levels, making them valuable for studying parathyroid physiology and calcium metabolism. They do not proliferate or undergo passaging, and repeated freeze-thaw cycles should be avoided to preserve viability.

Species

Human
Cat.No

ABC-TC110L
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Parathyroid Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Parathyroid
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Parathyroid Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Parathyroid Cells are widely utilized in research on calcium homeostasis, endocrine regulation, and parathyroid-related diseases. They provide an effective in vitro model to study PTH secretion dynamics, calcium-sensing receptor signaling, and mechanisms of parathyroid hyperplasia and adenoma formation. These cells also support drug screening for agents targeting PTH regulation or calcium metabolism disorders. Furthermore, they are valuable in investigating molecular pathways underlying metabolic bone diseases such as osteoporosis and chronic kidney disease–associated mineral imbalance.

Citation

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Frequently Asked Questions

  • What are Human Parathyroid Cells?

    Human parathyroid cells are specialized cells located in the parathyroid glands, which are small endocrine glands situated behind the thyroid gland. These cells play a crucial role in regulating calcium levels in the blood by secreting parathyroid hormone (PTH).

  • What is the primary function of parathyroid hormone (PTH)?

    PTH regulates calcium and phosphate levels in the blood. It increases blood calcium levels by stimulating the release of calcium from bones, increasing calcium absorption in the intestines, and promoting calcium reabsorption in the kidneys.

  • What are the primary applications of human parathyroid cells in research?

    These cells are used in various research applications including studies on calcium homeostasis, bone metabolism, endocrine function, and the development of treatments for parathyroid-related disorders such as hyperparathyroidism and hypoparathyroidism.

  • What are the key markers used to identify human parathyroid cells?

    Key markers for human parathyroid cells include parathyroid hormone (PTH) and calcium-sensing receptors (CaSR). These markers are used to confirm the identity and purity of the cells in research studies.

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