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Human PDGFRa (D842V_G652E) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PDGFRa (D842V_G652E) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0029C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human PDGFRa (D842V_G652E) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. PDGFRa (D842V_G652E) BAF3 mutant cell line is generated by stable integration of exogenous human PDGFRA gene harboring dual mutations (D842V and G652E) into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
PDGFRA encodes the alpha isoform of platelet-derived growth factor receptor, a type III receptor tyrosine kinase. The D842V mutation is a known activating variant in gastrointestinal stromal tumors (GIST), and the G652E mutation has been associated with enhanced receptor activity and drug resistance. Dual mutations confer constitutive activation and resistance to first-line TKIs. AcceGen offers generation of stable overexpression and compound mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PDGFRa (D842V_G652E) BAF3 Cell Line serves as a powerful tool to investigate drug resistance and PDGFRA signaling. This model enables mechanistic studies of constitutive kinase activation, downstream signaling engagement, and preclinical testing of next-generation PDGFRA inhibitors. It is utilized for GIST research and therapeutic development.

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