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Transfected Stable Cell Lines

Human PIK3CA (E545K) SK-BR-3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PIK3CA (E545K) SK-BR-3 Cell Line
Species

Human
Cat.No

ABC-X0085C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Breast
Disease

Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

SK-BR-3

Description

Human PIK3CA (E545K) SK-BR-3 Cell Line is a genetically engineered model derived from selected human SK-BR-3 parental cell line based on customers’ requirement. PIK3CA (E545K) SK-BR-3 mutant cell line is generated by stable integration of exogenous human PIK3CA gene harboring the E545K mutation into SK-BR-3 host cells using our optimized transduction of lentiviral vectors.
Target
PIK3CA plays a pivotal role in cell growth, survival, and metabolism. The E545K mutation occurs within the helical domain and is a driver alteration in multiple cancers, leading to constitutive PI3K pathway activation. It is often used as a biomarker for patient stratification in clinical oncology. AcceGen offers generation of stable overexpression and clinically relevant mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PIK3CA (E545K) SK-BR-3 Cell Line serves as a powerful tool to evaluate helical domain-specific oncogenic mechanisms and drug response. This model enables pharmacological screening of PI3K inhibitors and studies of resistance mechanisms in breast cancer and beyond. It is utilized in functional genomics and translational oncology research.

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