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Human PIK3CA (H1047L) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PIK3CA (H1047L) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0058C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human PIK3CA (H1047L) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. The PIK3CA (H1047L) mutant cell line is generated by stable integration of exogenous human PIK3CA gene carrying the H1047L point mutation into Ba/F3 host cells using optimized lentiviral transduction.
Target
PIK3CA encodes the p110α catalytic subunit of class IA PI3K, which regulates critical cellular processes via the PI3K/AKT/mTOR pathway. The H1047L mutation, located in the kinase domain, results in constitutive activation of downstream signaling and is frequently observed in breast, colorectal, and endometrial cancers. AcceGen provides mutant-specific cell lines to support precision oncology studies. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PIK3CA (H1047L) BAF3 Cell Line serves as an effective model for studying oncogenic PI3K activation, signal transduction, and therapeutic response to PI3K pathway inhibitors. It supports mechanistic research and targeted drug screening.

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