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Human PIK3CA (H1047R) SK-BR-3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PIK3CA (H1047R) SK-BR-3 Cell Line
Species

Human
Cat.No

ABC-X0084C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Breast
Disease

Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

SK-BR-3

Description

Human PIK3CA (H1047R) SK-BR-3 Cell Line is a genetically engineered model derived from selected human SK-BR-3 parental cell line based on customers’ requirement. PIK3CA (H1047R) SK-BR-3 mutant cell line is generated by stable integration of exogenous human PIK3CA gene harboring the H1047R hotspot mutation into SK-BR-3 host cells using our optimized transduction of lentiviral vectors.
Target
PIK3CA encodes the p110α catalytic subunit of class I phosphoinositide 3-kinase (PI3K), involved in the PI3K/AKT/mTOR signaling pathway. The H1047R mutation is a common oncogenic alteration that enhances PI3K kinase activity and promotes tumorigenesis. It is frequently observed in breast, colon, and endometrial cancers. AcceGen offers generation of stable overexpression and point-mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PIK3CA (H1047R) SK-BR-3 Cell Line serves as a powerful tool to investigate PI3K-driven oncogenic signaling and drug resistance mechanisms. This model enables functional assays of targeted PI3K inhibitors, pathway activation profiling, and precision medicine studies. It is utilized in cancer therapeutics development and biomarker validation.

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