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Primary Cells

Human Pulmonary Fibroblasts

  • For research use only

Cat No.

ABC-TC3776
Product Type

Pulmonary Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Storage

Liquid Nitrogen

HPF from AcceGen Research Laboratories are isolated from human lung tissue.

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  • Human Pulmonary Fibroblasts
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Pulmonary Fibroblasts

Description

Human Pulmonary Fibroblasts (HPF) are primary mesenchymal cells isolated from normal human lung parenchyma. These adherent, spindle-shaped cells exhibit a typical fibroblastic morphology and are maintained at early passage to preserve native phenotypes. HPFs express markers such as vimentin and fibronectin, with context-dependent expression of α-smooth muscle actin (α-SMA) depending on activation status. These cells are capable of synthesizing extracellular matrix components (e.g., collagen I, III, elastin) and respond robustly to profibrotic stimuli like TGF-β1. Their proliferative and migratory capacities make them valuable for modeling tissue repair and fibrosis. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Human Pulmonary Fibroblasts, Lung Fibroblasts, HPFs (Lung), Pulmonary Stromal Fibroblasts
Species

Human
Cat.No

ABC-TC3776
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Pulmonary Fibroblasts (HPFs), also known as primary human lung fibroblasts or human respiratory stromal cells, are widely used in pulmonary fibrosis research, including studies on idiopathic pulmonary fibrosis (IPF), fibroblast-to-myofibroblast transition, and ECM remodeling. They serve as a platform to investigate signaling pathways like TGF-β/SMAD, Wnt/β-catenin, and MAPK, which are central to fibrotic lung disease. HPFs are also valuable in drug discovery for testing anti-fibrotic agents. In co-culture or 3D models, HPFs enable investigation of fibroblast–epithelial–immune cell crosstalk, modeling chronic lung disease, tissue regeneration, and lung cancer–associated stroma.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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