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Primary Cells

Human Pulmonary Microvascular Endothelial Cells

  • For research use only

Cat No.

ABC-TC3779
Product Type

Pulmonary Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Storage

Liquid Nitrogen

Human Pulmonary Microvascular Endothelial Cells support lung vascular biology, permeability modeling, and inflammatory response studies in lung tissue.

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  • Human Pulmonary Microvascular Endothelial Cells
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Pulmonary Microvascular Endothelial Cells

Description

Human Pulmonary Microvascular Endothelial Cells (HPMECs) are primary endothelial cells isolated from the microvasculature (capillary bed) of healthy human lung tissue. These adherent cells exhibit a cobblestone-like morphology when confluent and maintain strong proliferative capacity at early passages. HPMECs express specific endothelial markers such as CD31 (PECAM-1), VE-cadherin, von Willebrand factor (vWF), and vascular endothelial growth factor receptor 2 (VEGFR2/KDR). They retain the ability to form capillary-like structures in vitro, internalize acetylated LDL, and bind Ulex europaeus lectin, confirming their microvascular phenotype. HPMECs are highly responsive to hypoxia, inflammation, and angiogenic stimuli, making them an excellent model for lung-specific vascular biology. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Human Pulmonary Microvascular Endothelial Cells, HPMECs, Lung Microvascular ECs, Pulmonary MVECs
Species

Human
Cat.No

ABC-TC3779
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Pulmonary Microvascular Endothelial Cells (HPMECs), also referred to as primary lung capillary endothelium or human lung microvascular cells, are ideal for studying lung-specific microvascular physiology, including vascular permeability, angiogenesis, and barrier function under various stimuli (e.g., LPS, hypoxia, cytokines). They are critical for modeling acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and pulmonary inflammation, as well as for investigating leukocyte–endothelial interactions, tight junction dynamics, and vascular leak syndromes. HPMECs also support drug screening for anti-inflammatory, anti-angiogenic, or endothelium-stabilizing compounds, especially in the context of lung injury and chronic pulmonary vascular diseases.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Were these cells validated as Human Pulmonary Microvascular Endothelial Cells? What markers were used?

    Yes. These cells are validated as Human Pulmonary Microvascular Endothelial Cells. CD31 (PECAM-1) immunofluorescence staining is positive, supporting their endothelial identity.

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