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Primary Cells

Human Astrocytes-Retina

  • For research use only

Cat No.

ABC-TC3787
Product Type

Ocular Cells
Cell Type

Astrocyte
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Storage

Liquid Nitrogen

Human retinal astrocytes support ganglion cells, maintain blood-retinal barrier, and aid retinal disease research; avoid freeze-thaw cycles.

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  • Human Astrocytes-Retina
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Astrocytes-Retina

Description

Human Retinal Astrocytes are primary cells isolated from human retinal tissue, primarily localized in the nerve fiber layer and optic nerve head. These cells display characteristic star-shaped morphology with extended processes and form extensive contacts with retinal ganglion cell axons, reflecting the close retinal nerve connections supported by astrocytes. Functionally, retinal astrocytes provide critical structural and metabolic support to retinal neurons, regulate extracellular ion and neurotransmitter homeostasis, and contribute to maintaining blood–retinal barrier integrity through coordinated astrocyte signaling in the retina and neurovascular interactions. They express key astrocytic markers such as GFAP and S100β and play essential roles in retinal homeostasis, neurovascular coupling, and neuroprotection mediated by retinal astrocytes under physiological and stress conditions. Dysfunction or dysregulation of these cells is closely associated with retinal pathologies including glaucoma, diabetic retinopathy, and ischemic retinopathies, making them highly relevant for human eye glial studies focused on retinal disease mechanisms. To maintain optimal physiological function and cell viability, repeated freeze–thaw cycles should be minimized during culture.

Product Code

HRA
Species

Human
Cat.No

ABC-TC3787
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Astrocyte
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Ocular Cells

Application

  • Human Retinal Astrocytes are widely used to study retinal neurovascular interactions, blood-retinal barrier integrity, and glial responses to injury and disease. They provide a relevant in vitro model for investigating mechanisms of neuroinflammation, gliosis, and vascular dysfunction in diseases such as glaucoma and diabetic retinopathy. These cells are ideal for drug screening targeting neuroprotection and anti-inflammatory pathways, as well as co-culture systems with retinal neurons and endothelial cells to explore cell-cell communication within the retina.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Retinal Astrocytes?

    Human Retinal Astrocytes are glial cells found in the retina, where they provide structural and functional support to neurons and blood vessels. They play a key role in maintaining retinal homeostasis, regulating the blood-retinal barrier, and responding to injury or disease.

  • What role do Human Retinal Astrocytes play in response to retinal injury?

    When the retina is damaged, retinal astrocytes become reactive, proliferating and releasing signaling molecules that mediate inflammation and repair. This process, known as gliosis, can either support regeneration or contribute to scarring depending on the extent of injury.

  • Can Human Retinal Astrocytes be used to model retinal diseases?

    Yes, Human Retinal Astrocytes are valuable in modeling retinal diseases, particularly those involving neurodegeneration and vascular dysfunction. They are used to study conditions such as glaucoma, age-related macular degeneration, and retinal ischemia.

  • What are the typical culture conditions for Human Retinal Astrocytes?

    These cells are cultured in a specialized medium enriched with factors that support astrocyte growth and function, such as neurotrophic factors. They thrive in environments at 37°C with 5% CO2, mimicking the physiological conditions of the retina.

  • What is the significance of Human Retinal Astrocytes in retinal neurovascular coupling?

    Retinal astrocytes play a key role in neurovascular coupling, which is the process by which neuronal activity regulates blood flow in the retina. They mediate communication between neurons and blood vessels, ensuring adequate blood supply in response to retinal activity.

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