Human Sjogren Syndrome Peripheral Blood Mononuclear Cells

Description

Human Sjogren Syndrome Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of patients with Sjogren Syndrome (SS) and are mainly composed of lymphocytes (T cells, B cells, NK cells), monocytes and dendritic cells. SS is an autoimmune exocrinopathy characterized by lymphocytic infiltration of salivary/lacrimal glands, leading to sicca symptoms and systemic extraglandular manifestations. These PBMCs are round mononuclear cells, grow in non-adherent suspension culture. They play a core role in the SS pathogenesis, and the imbalance of T cell subsets promoting inflammatory infiltration of glandular tissue. B cells produce autoantibodies (anti-Ro/SSA, anti-La/SSB) and in turn elevate IFN-γ secretion, altere T cell subset ratios (Th1/Th2 imbalance). In addition, abnormal cytokine secretion of PBMCs (such as IFN-γ) exacerbates the autoimmune response. PBMCs contribute to glandular inflammation and tissue damage through autoimmune mechanisms and cytokine dysregulation. These PBMCs provide a valuable platform for studying adaptive immunity in Sjogren’s, enabling comprehensive PBMC profiling Sjogren syndrome and detailed analysis of the Sjogren syndrome immune response in both glandular and systemic contexts.