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Human Sjogren Syndrome Peripheral Blood Mononuclear Cells

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Sjogren syndrome (SjS, SS) is a long-term autoimmune disease that affects the body&#39,s moisture-producing glands. Primary symptoms are a dry mouth and dry eyes. Other symptoms can include dry skin, vaginal dryness, a chronic cough, numbness in the arms and legs, feeling tired, muscle and joint pains, and thyroid problems. Those affected are at an […]
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Sjogren Syndrome Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4326
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Sjogren Syndrome
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Sjogren Syndrome Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with Sjogren Syndrome (SS) and are mainly composed of lymphocytes (T cells, B cells, NK cells), monocytes and dendritic cells. Round mononuclear cells; suspension culture; non-adherent.PBMCs play a core role in the SS pathogenesis, especially the overactivation of B cells leading to the production of autoantibodies (such as anti-Ro/SSA, anti-La/SSB), and the imbalance of T cell subsets promoting inflammatory infiltration of glandular tissue. Autoantibodies (anti-Ro/SSA, anti-La/SSB) production by B cells; elevated IFN-γ secretion; altered T cell subset ratios (Th1/Th2 imbalance)In addition, abnormal cytokine secretion of PBMCs (such as IFN-γ) exacerbates the autoimmune response.PBMCs contribute to glandular inflammation and tissue damage through autoimmune mechanisms and cytokine dysregulation.

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Application

  • Human Sjogren Syndrome Peripheral Blood Mononuclear Cells can be utilized to investigate the pathological mechanisms underlying Sjogren Syndrome-related diseases, facilitating the exploration of disease biomarkers and targeted therapeutic strategies. Additionally, they serve as a valuable model for evaluating the immunomodulatory effects of targeted therapies on abnormal immune responses in PBMCs.

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