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Human SLC34A2 ROS1 (D2033N) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human SLC34A2 ROS1 (D2033N) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0020C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The SLC34A2 ROS1 (D2033N) BAF3 Cell Line expresses the human SLC34A2-ROS1 fusion gene carrying a D2033N resistance mutation. Generated via lentiviral integration, this model recapitulates ROS1 fusion-driven oncogenesis with acquired resistance.
Target
The SLC34A2-ROS1 fusion encodes a constitutively active receptor tyrosine kinase implicated in NSCLC. The D2033N mutation confers resistance to ROS1 inhibitors like crizotinib by altering the kinase domain. This model aids in dissecting resistance mechanisms and evaluating next-generation inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The SLC34A2 ROS1 (D2033N) BAF3 Cell Line enables screening of ROS1 inhibitors, elucidation of resistance pathways, and mechanistic studies of ROS1-driven oncogenesis, particularly in lung cancer settings.

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