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Human SLC34A2_ROS1 (D2113G) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human SLC34A2_ROS1 (D2113G) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0066C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human SLC34A2_ROS1 (D2113G) BAF3 Cell Line is a genetically engineered model derived from the murine pro-B cell line BAF3 based on customers’ requirement. This overexpression cell line is generated by stable integration of exogenous human SLC34A2_ROS1 (D2113G) fusion gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The SLC34A2_ROS1 (D2113G) fusion involves a solute carrier protein and the receptor tyrosine kinase ROS1, with a D2113G mutation. This alteration is linked to constitutive ROS1 activation, driving oncogenic pathways such as PI3K/AKT and MAPK. ROS1 fusions are key therapeutic targets in non-small cell lung cancer. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The Human SLC34A2_ROS1 (D2113G) BAF3 Cell Line supports investigation of ROS1 mutation-mediated oncogenesis and facilitates development of ROS1-targeted inhibitors. It provides a robust system for resistance modeling and drug efficacy testing.

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