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Human SLC43A2_ROS1 (S1986F) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human SLC43A2_ROS1 (S1986F) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0090C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human SLC43A2_ROS1 (S1986F) BAF3 Cell Line is a murine pro-B cell model derived from Ba/F3 cells, modified to express the SLC43A2-ROS1 fusion carrying an S1986F mutation. Stable integration is achieved using lentiviral vectors, and qRT-PCR confirms transgene expression. Cells are expanded below P20.
Target
SLC43A2-ROS1 fusions activate oncogenic ROS1 kinase signaling, and the S1986F variant may influence therapeutic response and signaling strength. ROS1 fusion proteins activate PI3K-AKT, MAPK, and STAT pathways, supporting tumor progression. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This engineered model provides a platform for dissecting oncogenic mechanisms of ROS1 fusions and for evaluating the efficacy of novel ROS1 inhibitors, especially in the context of mutation-driven resistance.

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