Human Stomach Cancer Peripheral Blood Mononuclear Cells

Description

Human Stomach Cancer Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with gastric cancer mainly consist lymphocytes (T cells, B cells, NK cells) and monocytes. As an important component of the immune system, PBMCs play a key role in the gastric cancer microenvironment: CD8+ T cells mediate tumor cell killing, regulatory T cells (Treg) participate in immune tolerance, and monocytes can differentiate into tumor-associated macrophages (TAMs) to promote angiogenesis and metastasis. Studies have shown that upregulated expression of PD-1/CTLA-4 and imbalance of Th1/Th2 ratio in PBMCs of patients with gastric cancer are associated with disease progression.

Application

• Human Stomach Cancer Peripheral Blood Mononuclear Cells can be used to explore the tumor immune microenvironment, evaluate treatment response, and develop new immunotherapies. They can also be used to analyze changes in gastric cancer-related immune cell subsets, such as the expansion of regulatory T cells (Treg), CD8+ T cell function exhaustion.