Human Thyroid Cancer Peripheral Blood Mononuclear Cells

Description

Human Thyroid Cancer Peripheral Blood Mononuclear Cells are immune cell populations isolated from the peripheral blood of thyroid cancer patients, mainly including lymphocytes (T cells, B cells, NK cells) and monocytes.Typical mononuclear morphology with round lymphocytes and monocytes exhibiting kidney-shaped or lobed nuclei.PBMCs participate in antitumor immune responses, including antigen presentation (monocytes/macrophages), cytotoxicity (NK cells and CD8+ T cells), and antibody secretion (B cells) [1-4]. In thyroid cancer, PBMCs participate in tumor immune surveillance and regulate the tumor microenvironment, but their functions may be inhibited or dysregulated by tumor immune escape mechanisms (such as PD-L1 upregulation, T cell exhaustion). Functional impairment due to tumor immune escape mechanisms affecting cytotoxicity and antigen presentation

Application

• Human Thyroid Cancer Peripheral Blood Mononuclear Cells can be used to study the mechanism of tumor immune escape, evaluate the efficacy of immunotherapy, and find biomarkers for disease monitoring. In addition, the analysis of this cell population provides an important basis for the development of immunotherapy strategies for advanced or refractory thyroid cancer.