Human TNK1_AAA BAF3 Cell Line

Description

Human TNK1_AAA BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. TNK1_AAA BAF3 overexpression cell line is generated by stable integration of exogenous human TNK1 gene carrying AAA mutation into BAF3 host cells using our optimized transduction of lentiviral vectors. The edited cells are maintained at low passage numbers (<P20). Overexpression clone is validated at gene level by qRT-PCR. Target The TNK1 gene encodes a non-receptor tyrosine kinase involved in cell growth suppression and signal transduction. The AAA mutation disrupts its autoinhibitory function, leading to hyperactivation of downstream pathways such as Ras and STAT signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.