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Primary Cells

Human Ulcerative Colitis Peripheral Blood Mononuclear Cells

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    1

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Peripheral blood mononuclear cells are isolated from Ulcerative Colitis peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh Ulcerative Colitis PBMCs is available upon request.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Ulcerative Colitis Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4267
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Ulcerative Colitis
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Ulcerative Colitis Peripheral Blood Mononuclear Cells (UC-PBMCs) are isolated from the peripheral blood of patients with ulcerative colitis, mainly including T cells, B cells, NK cells and monocytes. UC-PBMCs play a core role in immune regulation and mediate the chronic inflammatory response of UC. Typical mononuclear cells with round or oval nuclei, suspension growth Among them, Th2 cells and innate immune cells (such as monocytes) are overactivated, leading to increased secretion of proinflammatory factors (IL-6, TNF-α) and damage to the intestinal mucosal barrier [1-3]. Overactivation markers on Th2 cells and monocytes; increased proinflammatory cytokines (IL-6, TNF-α).In addition, defective regulatory T cells (Treg) function may aggravate autoimmune reactions. Defective Treg function contributing to immune dysregulation and chronic inflammation.

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Application

  • Human Ulcerative Colitis Peripheral Blood Mononuclear Cells can be used as an in vitro cell model to study the molecular mechanism of chronic inflammation of the intestinal mucosa. These cells can also be used as a disease biomarker or drug target screening model to provide a basis for the development of anti-inflammatory therapies (such as JAK inhibitors).

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