Human Ulcerative Colitis Peripheral Blood Mononuclear Cells

Description

Human Ulcerative Colitis Peripheral Blood Mononuclear Cells (Human UC PBMCs) are isolated from the peripheral blood of patients with ulcerative colitis, mainly including T cells, B cells, NK cells and monocytes. Human UC PBMCs play a core role in immune regulation and mediate the chronic inflammatory response of UC. Typical mononuclear cells with round or oval nuclei, suspension growth. Among these, Th2 cells and innate immune cells (e.g., monocytes) are overactivated, resulting in excessive secretion of proinflammatory cytokines (IL-6, TNF-α) and damage to the intestinal mucosal barrier. This is evidenced by elevated activation markers on Th2 cells and monocytes, along with increased levels of proinflammatory cytokines (IL-6, TNF-α). Additionally, impaired function of regulatory T cells (Tregs) may exacerbate autoimmune responses, contributing to immune dysregulation and chronic inflammation. In translational research, these samples are utilized for detailed analysis of cytokine expression in UC, characterization of T cell subsets in ulcerative colitis, investigation of the B cell role in UC, and comprehensive PBMC phenotyping UC to better understand disease mechanisms and identify therapeutic targets.

Application

• Human Ulcerative Colitis Peripheral Blood Mononuclear Cells can be used as an in vitro cell model to study the molecular mechanism of chronic inflammation of the intestinal mucosa. These cells can also be used as a disease biomarker or drug target screening model to provide a basis for the development of anti-inflammatory therapies (such as JAK inhibitors).