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Human Vitiligo Peripheral Blood Mononuclear Cells

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Vitiligo is a disease in which the pigment cells of the skin, melanocytes, are destroyed in certain areas.&nbsp,Clinical data may include: Medication (current and historical), Disease severity, VASI Score.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Vitiligo Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4353
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Vitiligo
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Vitiligo Peripheral Blood Mononuclear Cells are a population of mononuclear cells isolated from the peripheral blood of patients with vitiligo, mainly including lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs are typically round or oval. In vitiligo, PBMCs (especially autoreactive CD8+ T cells) mediate cytotoxicity by recognizing melanocyte antigens (such as tyrosinase-related protein 1/2), leading to melanocyte destruction and skin depigmentation. In addition, abnormal function of regulatory T cells (Treg) and increased secretion of proinflammatory cytokines (such as IFN-γ, TNF-α) further drive autoimmune responses.

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Citation

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Application

  • Human Vitiligo Peripheral Blood Mononuclear Cells can be used to investigate the immunological mechanism of vitiligo. They can also be used to evaluate the cytotoxic effect of PBMCs on melanocytes, thereby identifying potential pathogenic T cell subsets. These cells can also be applied to test the efficacy of immunomodulatory therapies (such as JAK inhibitors, IL-15 antagonists) and evaluate their inhibitory effects on T cell activation and cytokine release.

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