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| Product Code | IGR 1; IGR1 |
| Species | Human |
| Cat.No | ABC-TC537S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Groin Lymph Node |
| Disease | Melanoma |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
IGR-1 is a human melanoma cell line derived from the inguinal lymph node metastasis of a 42-year-old male patient. It displays epithelial-like morphology and exhibits adherent growth properties. Genetically, IGR-1 carry key oncogenic mutations in BRAF (p.Val600Lys) and RAC1 (p.Pro29Ser), both of which are implicated in melanoma pathogenesis and tumor progression.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Liao, Y., Jia, X., Ren, Y., Deji, Z., Gesang, Y., Ning, N., Feng, H., Yu, H. and Wei, A., 2021. Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation. Human Cell, pp.1-13.
Gill, Jennifer G et al. “A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma.” Cancer research vol. 82,7 (2022): 1251-1266. doi:10.1158/0008-5472.CAN-21-2062
The IGR-1 cell line plays a pivotal role in advancing the understanding of human melanoma biology, particularly in the context of oncogenic signaling, metabolic regulation, and cell proliferation mechanisms. It is widely used to investigate the molecular pathways driven by BRAF and RAC1 mutation, supporting preclinical studies aimed at identifying novel therapeutic targets. Additionally, IGR-1 contributes to crucial insights into melanoma research, researchers could explore drug resistance and evaluate the efficacy of potential therapeutic interventions in melanoma, contributing to the development of more effective treatment strategies.
