For research use only
| Cat No. | ABC-TC0027 |
| Product Type | Human Melanoma Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Malignant Melanoma |
| Product Code | A-375P; A375-P; A375p |
Tumorigenecity: Isoenzyme: Histopathology: melanoma, low metastaticSubculture: Split ratio: Media change: Reverse transcritase: Production
A375P cell line is a subline of the human malignant melanoma cell line A375. Derived from a primary tumor of a 54-year-old female, A375P exhibits epithelial-like, adherent growth and a hypotriploid karyotype. The cells display typical melanoma features such as BRAF V600E mutation, MITF expression, and moderate melanin production under specific culture conditions. They demonstrate low invasive potential compared to A375SM or A375M sublines, forming fewer and smaller colonies in soft agar and exhibiting reduced migration in transwell assays. Proteomic profiling confirms stable expression of melanocytic markers and lower levels of mesenchymal markers like vimentin and N-cadherin, consistent with its low metastatic behavior. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | A-375P; A375-P; A375p |
| Species | Human |
| Cat.No | ABC-TC0027 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Malignant Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
A375P serves as a valuable model for comparative studies of melanoma metastasis and drug resistance. It is used to quantify differences between low and high metastatic variants, enabling research into invasion mechanisms, EMT regulation, and metastatic suppressor gene functions. It has also been applied in zebrafish xenograft assays, showing limited tumor growth compared to more aggressive sublines, making it a useful tool for preclinical screening of anti-metastatic agents.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
