+1 862-686-2696
Featured Products
Primary Cells
Immortalized Cell Lines
Stem Cells
Tumor Cell Lines
Transfected Stable Cell Lines
Exosomes
MicroRNA Agomir/Antagomir
Nucleic Acid Kits
Explore Products
Cell
Cell
MicroRNA
MicroRNA
Test and Analysis
Test and Analysis
Immortalized Cell Lines

Immortalized Human Hepatocytes

  • 452
The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.
Request Your Custom Quote Today

Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.

Get a Quote
  • High Purity Levels
  • Precision and Reliability
  • Customization Options
Home | Immortalized Cell Lines | Immortalized Human Hepatocytes
Species

Human
Cat.No

ABI-TC3500
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Hepatocyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line

Description

Immortalized Human Hepatocytes (IHH) are liver cells that have been genetically modified to extend their functional lifespan in culture, maintaining stable characteristics during short-term cultivation. These cells have shown promise in therapeutic applications, such as improving survival rates in preclinical models of acute liver failure when transplanted before the onset of severe damage.

IHH do not proliferate indefinitely, but they still offer significant value in liver disease research and potential therapeutic use due to their sustained functionality over short periods. Advances in cellular modification techniques, including telomerase activation via human telomerase reverse transcriptase (hTERT) and alterations in key regulatory pathways (such as p16/RB or p53), enhance the potential for their use in diverse applications. IHH are emerging as a critical resource in the development of cell-based therapies for liver-related disorders.

Immortalized Human Hepatocytes

Why choose Immortalized human hepatocytes from AcceGen?

AcceGen pioneers the field of biomedical research with its cutting-edge immortalized human hepatocytes (IHH), meticulously crafted through advanced genetic modifications. Our IHH undergo rigorous quality control tests, ensuring the highest standards for your research needs:

 

Sterility Assurance

Rigorously tested for bacterial, fungal, Mycoplasma (PCR), and human pathogen contamination, guaranteeing pristine cell cultures.

 

Viability Excellence

Boasting over 95% post-thaw viability, our IHH exhibit robustness and resilience crucial for consistent and reliable experimental outcomes.

 

Identity Verification

Through Short Tandem Repeat (STR) analysis featuring 16 probes, including 15 STR loci and Amelogenin, we ascertain the precise genetic identity of our immortalized hepatocytes.

 

Growth Optimization

Evaluated based on morphology and immunocytochemistry of multiple undifferentiation markers, our IHH maintain characteristics akin to primary hepatocytes, ensuring authenticity in your studies.

AcceGen Frozen Cells & Cell Lines 1 vial
View Product Image

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • FOR RESEARCH USE ONLY

  •  

  • Immortalized human hepatocytes find diverse applications in scientific research, particularly in the field of hepatology and related areas. Some key applications include:

  •  

  • Biomedical Research

  • Immortalized human hepatocytes serve as crucial tools for studying liver-related diseases, enabling researchers to explore the molecular mechanisms underlying conditions such as hepatitis, cirrhosis, and liver cancers. These cells provide valuable insights into disease progression and potential therapeutic targets.

  •  

  • Drug Metabolism Studies

  • Researchers use immortalized human hepatocytes to assess drug metabolism and toxicity. These cells mimic the metabolic functions of primary hepatocytes, allowing for the evaluation of drug interactions, metabolite profiling, and the identification of potential adverse effects on the liver.

  •  

  • Cell-Based Therapies

  • The immortalization of hepatocytes contributes to the development of cell-based therapies for liver diseases. These cells can potentially be utilized for transplantation purposes, aiding in the regeneration of damaged liver tissue and offering novel therapeutic approaches for acute liver failure and other liver disorders.

  •  

  • Disease Modeling

  • Immortalized hepatocytes are employed to create in vitro models for various liver diseases. These models help researchers investigate the pathophysiology of diseases, test therapeutic interventions, and develop new treatment strategies.

  •  

  • Functional Studies

  • Researchers use immortalized hepatocytes to conduct functional studies related to liver physiology. This includes exploring signaling pathways, cytokine production, and responses to external stimuli, providing a comprehensive understanding of hepatocellular functions.

  •  

  • Viral Infection Studies

  • Immortalized hepatocytes are instrumental in studying viral infections affecting the liver, such as hepatitis viruses. Researchers can investigate the host-virus interactions, viral replication cycles, and the impact of antiviral drugs on infected hepatocytes.

  •  

Frequently Asked Questions

  • What are immortalized human hepatocytes?

    Immortalized human hepatocytes are liver cells that have been genetically modified to proliferate indefinitely. This is typically achieved by introducing specific genes or using viral vectors that prevent the cells from undergoing senescence, thereby allowing continuous cell division and growth. These cells retain many of the functional characteristics of primary hepatocytes, making them valuable for research and therapeutic purposes.

  • How are immortalized human hepatocytes used in research?

    Immortalized human hepatocytes are used extensively in research to study liver function, drug metabolism, and toxicity. They provide a stable and consistent model for investigating hepatic diseases, including hepatitis and liver cancer.

  • What are the benefits of using immortalized human hepatocytes?

    Prolonged Lifespan: They can be cultured for extended periods, providing a consistent and renewable cell source.

    Liver-Specific Functions: They retain many characteristics of primary hepatocytes, such as enzyme activity related to drug metabolism.

    Reproducibility: Their continuous growth allows for reproducible experiments and large-scale studies.

  • Online Inquiry
  • Product Reviews

Inquiring Immortalized Human Hepatocytes

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

Let's Advance Life Science Research Together

Contact Us
AcceGen Scroll Top Button