Immortalized Human Synoviocytes

Description

Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. They form a distinct structure called the synovial lining layer. Synoviocytes produce synovial fluid, are responsible for absorption from the joint cavity and are also in control of blood/synovial fluid exchanges. Synoviocytes proliferate, show anchorage-independent growth, and secrete a variety of effector molecules that promote inflammation and joint destruction.