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Kelly

Product Name

Kelly

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Product Code

KELLY; NB19; NB-19; NB19-RIKEN

Cat.No

ABC-TC548S

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The Kelly cell line is a human neuroblastoma cell line characterized by genomic amplification of the N-myc gene, leading to elevated levels of N-myc RNA or protein expression. These cells primarily exhibit neuroblastic phenotypes and show partial differentiation towards a neuronal phenotype when exposed to retinoic acid (RA) or herbimycin A (herb-A). They are sensitive to a combination of RA and herb-A, which reduces cell growth and colony formation. In culture, Kelly cells are adherent, round to fusiform in shape, with polar neuritic processes, growing in both mono- and multilayers. They are also tumorigenic in nude mice, and for subculturing, sub-confluent cultures (70-80%) are typically split at ratios ranging from 1:5 to 1:20.

 

Why choose Kelly from AcceGen?

The Kelly cell line from AcceGen offers high viability and quality, making it ideal for research. This cell line is confirmed to be negative for mycoplasma, as well as several viruses (EBV, HBV, HCV, HHV-8, HIV-1, HIV-2, HTLV-1/2, MLV, SMRV), and its identity is verified through STR analysis, ensuring its authenticity for research applications.

Source Organ

Brain

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

The Kelly cell line is a valuable tool in cancer research, particularly in the study of human neuroblastoma and the development of novel therapeutic strategies. Researchers have utilized this cell line to investigate the role of polysialic acid (PSA) in regulating tumor cell growth and differentiation by disrupting neural cell adhesion molecule (NCAM) signaling pathways. Additionally, the Kelly cell line has been instrumental in exploring the inhibitory role of protein tyrosine phosphatase SHP1 in Ret oncogene activity. These applications provide critical insights into neuroblastoma biology and offer potential avenues for the development of targeted therapies.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Neuronal

Growth Mode

Adherent

Product Type

Human Nerve Tumors Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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