For research use only
| Cat No. | ABC-TC0569 |
| Product Type | Mouse Lymphoma Cell Lines |
| Cell Type | Murine T cell Lymphoma cell line |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | L5178R, L5178 R, l5178-r |
This cell line was derived from the L5178 thymic lymphoma induced by methylcholanthrene in a DBA/2 mouse.
L5178‑R is a murine T‑cell lymphoma cell line derived from a methylcholanthrene‑induced thymic lymphoma in a DBA/2 mouse and is extensively used as a model of transformed lymphoid cells with distinct radiation response phenotypes. The cells grow in suspension with lymphoblast morphology and are characterized by resistance to X‑ray irradiation but sensitivity to ultraviolet radiation, heat, and certain chemotherapeutic agents such as cis-platinum compounds, reflecting altered DNA damage responses. Over long‑term culture, L5178‑R can convert to an X‑ray sensitive variant (L5178‑S), demonstrating phenotypic shifts in radiation and repair pathways. Comparative studies with related lymphoma strains indicate that differences in DNA repair efficiency and apoptosis contribute to the distinct radiosensitivity profiles of L5178 sublines. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | L5178R, L5178 R, l5178-r |
| Species | Mouse |
| Cat.No | ABC-TC0569 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Murine T cell Lymphoma cell line |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Lymphoma Cell Lines |
L5178‑R is used as an in vitro murine lymphoma model for studies of radiation biology, DNA damage response, and differential repair mechanisms in transformed lymphoid cells. It supports investigation of clastogenic and mutagenic responses, comparative radiation sensitivity between resistant and sensitive sublines, analysis of DNA repair pathways, and screening of genotoxic agents. The line is also applied in toxicology and mutagenicity assays to assess chemical and radiation effects on mammalian lymphoma cells and DNA integrity.
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