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| Product Code | NCTC 929; NCTC-929; NCTC929; NCTC-929L; L cell; L cells; L-cell; L-cells; L cell line; L; Strain L-929; L-929; L 929; L929(NCTC); Clone 929 |
| Species | Mouse |
| Cat.No | ABC-TC0576 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Adipose |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Fibroblas Lymphocytes Cell Lines |
L929 is a murine fibroblast cell line originally isolated from subcutaneous connective tissue of a male C3H/An mouse. These cells display a fibroblast-like elongated spindle-shaped cell shaped morphology and exhibit adherent growth characteristics. Thecell line typically presents a hyperdiploid karyotype with chromosome counts ranging from 65 to 68, typically 66 chromosomes. L929 cells are known for their high expression of tumor necrosis factor (TNF) receptors, rendering them particularly sensitive to tumor necrosis factor-alpha (TNF-α) treatment. L929 is generally considered non-tumorigenic under routine conditions. However, it has been reported to form tumors in SCID mice at high inoculation doses (e.g., >10^7 cells).
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L929 cells are widely used in biological science due to their versatility and functional relevance. They serve as a standard model for in vitro cytotoxicity assay, aiding in the evaluation of potential adverse effects of various compounds. Additionally, L929 cells serves as an alternative source of macrophage colony-stimulating factors (M-CSF), facilitating research in immunology and cell biology. Moreover, the protein composition found in the L929 supernatant offers valuable insights into the activation state during the differentiation of bone marrow-derived macrophages (BMDMs) Their robust response to stimuli also makes them valuble for research in immunology, inflammation, and drug screening.
