For research use only
| Cat No. | ABC-TC0576 |
| Product Type | Mouse Fibroblas Lymphocytes Cell Lines |
| Cell Type | Fibroblast |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Adipose |
| Disease | Normal |
| Product Code | NCTC 929; NCTC-929; NCTC929; NCTC-929L; L cell; L cells; L-cell; L-cells; L cell line; L; Strain L-929; L-929; L 929; L929(NCTC); Clone 929;NCTC clone 929 |
L929 murine fibroblast line shows spindle morphology, hyperdiploid karyotype, sensitive to TNF-α, mostly non-tumorigenic but forms tumors at high doses.
L929 is a murine fibroblast cell line originally isolated in 1948 from subcutaneous connective tissue of a male C3H/An mouse. These adherent cells display spindle-shaped morphology typical of fibroblasts and grow robustly as monolayers. The cell line typically presents a hyperdiploid karyotype with chromosome counts ranging from 65 to 68, the modal number is usually around 66. L929 cells are known for their high expression of tumor necrosis factor (TNF) receptors, rendering them particularly sensitive to tumor necrosis factor-alpha (TNF-α) treatment. L929 is generally considered non-tumorigenic under routine conditions. However, studies have shown that it’s possible to select for L929 cell variants with enhanced lung colonization ability and tumorigenic potential. L929 cells express fibroblast markers such as vimentin and collagen and produce extracellular matrix components, making them suitable for investigations into wound healing, inflammation, and tumor microenvironment interactions.
| Product Code | NCTC 929; NCTC-929; NCTC929; NCTC-929L; L cell; L cells; L-cell; L-cells; L cell line; L; Strain L-929; L-929; L 929; L929(NCTC); Clone 929;NCTC clone 929 |
| Species | Mouse |
| Cat.No | ABC-TC0576 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Adipose |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Fibroblas Lymphocytes Cell Lines |
L929 cells are widely used in biological science due to their versatility and functional relevance. They serve as a standard model for in vitro cytotoxicity assay, aiding in the evaluation of potential adverse effects of various compounds. Additionally, L929 cells serves as an alternative source of macrophage colony-stimulating factors (M-CSF), facilitating research in immunology and cell biology. Moreover, the protein composition found in the L929 supernatant offers valuable insights into the activation state during the differentiation of bone marrow-derived macrophages (BMDMs) Their robust response to stimuli also makes them valuble for research in immunology, inflammation, and drug screening.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
