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| Product Code | M210B4 |
| Species | Mouse |
| Cat.No | ABC-TC0622 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Bone Marrow Cell Lines |
M2-10B4 is a bone marrow-derived stromal cell line originally isolated from the hematopoietic tissue of a (C57BL/6J X C3H/HeJ)F1 hybrid mouse. These cells exhibit fibroblast-like morphology, and adhere to surfaces in a monolayer growth pattern. M2-10B4 expresses laminin and collagen IV, while lacking collagen I and Factor VIII expression. Functionally, M2-10B4 cells are capable to effectively sustain myelopoiesis for both human and murine hematopoietic cells during extended culture periods. Additionally, this cell line are also capable to support specific murine stromal cell-dependent pre-B cell lines, making it an excellent tool for in vitro research.
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M2-10B4 cells serve as a robust platform in a range of hematological and virological studies. They are particularly valuable for supporting the in vitro growth of murine cytomegalovirus (MCMV), thus enabling detailed investigations into MCMV pathogenesis. In co-culture systems, these cells provides a physiologically relevant stromal environment for exploring the regulation of hematopoietic stem cells (HSCs), aiding in the study of HSC maintenance, proliferation, and differentiation. Moreover, M2-10B4 is employed in models of osteogenic differentiation, contributing to the understanding of bone marrow stromal cell biology and bone tissue engineering.
