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| Product Code | MKN28; MKN 28 |
| Species | Human |
| Cat.No | ABC-TC0686 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Stomach |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Gastric Cancer Cell Lines |
MKN-28 is a human gastric tumor cell line originally derived from the metastatic lymph node of a 70-year-old Japanese male patient with well-differentiated adenocarcinoma of the stomach. The cell line displays morphological features of intestinal differentiation, such as cell polarity and microvilli with core filaments both in vitro and in nude mice. MKN-28 is known to carry mutations in the p53 gene (I251L) and the APC tumor suppressor gene, and it exhibits silenced CD44 expression, as well as reduced or absent E-cadherin and β-catenin expression, contributing to its malignant phenotype. MKN-28 has a hypotriploid karyotype and has been reported as cross-contaminated with MKN74, and is thus referred to as MKN-28/74 in current research. The line is tumorigenic but not known to be metastatic.
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The MKN-28 cell line holds significant applications in various areas of research related to human gastric cancer. It is widely used to study gene therapy approaches using exogenous p53, aiming to develop potential treatments for gastric cancer. Additionally, this cell line serves as a valuable model to examine the mechanisms of proliferation and invasion in gastric cancer cells. Moreover, MKN-28 is used to detect microsatellite instability, providing crucial information for making informed therapeutic decisions in the context of gastric cancer treatment strategies.
