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| Product Code | MKN28; MKN 28 |
| Species | Human |
| Cat.No | ABC-TC0686 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Stomach |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Gastric Cancer Cell Lines |
MKN-28 is a human gastric cancer cell line derived from well-differentiated adenocarcinoma with morphological features of intestinal differentiation, exhibiting cell polarity and microvilli with core-filaments both in vitro and in nude mice. 
This cell line is known to have mutations in the p53(I251L) and APC tumor suppressor genes, as well as silenced CD44 expression. The cell line shows a doubling time of approximately 29 hours, and for subculturing, a split ratio of 1/10 to 1/20 is typically used. However, it is important to note that MKN-28 has been reported as cross-contaminated with MKN74 and is therefore referred to as MKN-28/74 in current studies.
Why choose MKN-28 from AcceGen?
The MKN-28 cell line features high quality and viability, ensuring robust experimental results. The cells are free from Mycoplasma contamination, as they have been successfully eliminated using MC-210. Additionally, the cell line benefits from advanced cryopreservation techniques performed by a professional operator, ensuring optimal storage and preservation for long-term use.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The MKN-28 cell line holds significant applications in various areas of research related to human gastric cancer. It is extensively used to explore gene therapy involving exogenous p53 proteins, aiming to develop potential treatments for gastric cancer. Additionally, this cell line serves as a valuable model to investigate the mechanisms underlying cell proliferation and invasion in gastric cancer. Moreover, MKN-28 is utilized in the detection of microsatellite instability, providing crucial information for making informed therapeutic decisions in the context of gastric cancer treatment strategies.
