Monkey Dermal Fibroblasts

Description

Monkey Dermal Fibroblasts (MDFs) are primary fibroblasts isolated from dermal tissue of the Cynomolgus Monkey. These cells are of mesenchymal origin and exhibit a spindle-shaped or stellate morphology, characterized by elongated cytoplasmic processes and a flat, adherent growth pattern in vitro. These cells play a critical role in maintaining skin structure by secreting ECM components (e.g., collagen, elastin) and regulating tissue repair through proliferation, migration, and cytokine signaling (e.g., TGF-β, PDGF). They are also involved in inflammatory responses and fibrosis. MDFs typically express the fibroblast-associated marker Vimentin, which can be detected by immunofluorescence staining or related molecular assays for cell identification. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.