Mouse Hippocampal Astrocytes are primary cells isolated from the hippocampus of neonatal mice. These astrocytes, critical for neural functioning, form a tightly coupled network in the hippocampus, a key region for spatial memory. Disruption of this network can affect neuronal excitability and synaptic transmission. Inhibition of vesicle release impairs recognition memory, while chemogenetic activation enhances contextual fear memory, demonstrating their role in memory. Morphologically, they exhibit astrocytic characteristics and are GFAP – positive. They are tested free of HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. Ideal for investigating molecular mechanisms of astrocytic physiology and their influence on cognition, these cells provide a reliable platform for brain development studies.
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