Mouse Hippocampal Astrocytes

Description

Mouse Hippocampal Astrocytes are primary cells isolated from the hippocampus of neonatal mice. These astrocytes, critical for neural functioning, form a tightly coupled network in the hippocampus, a key region for spatial memory. Disruption of this network can affect neuronal excitability and synaptic transmission. Inhibition of vesicle release impairs recognition memory, while chemogenetic activation enhances contextual fear memory, demonstrating their role in memory. Morphologically, they exhibit astrocytic characteristics and are GFAP – positive. They are tested free of HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. Ideal for investigating molecular mechanisms of astrocytic physiology and their influence on cognition, these cells provide a reliable platform for brain development studies.

Application

• Investigating mouse hippocampal astrocytes provide critical insights into their region-specific roles, molecular regulation, and physiological characteristics. By studying these cells, researchers can unravel the molecular controls that shape astrocytic fate and physiology, as well as understand how evolutionary changes in astrocytes influence advanced cognitive processes. Furthermore, exploring the role of astrocytes in neural signaling and cognitive integration enhances our understanding of brain function. Although much of our knowledge about astrocytes comes from in vitro studies, the continued use of astrocyte cultures in experimental research enables the exploration of the diverse properties of astrocytes and their contributions to brain function.