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| Species | Human |
| Cat.No | ABC-TC1342 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
NCI-H460 is a human large cell lung carcinoma cell line established in 1982 from the pleural effusion of a 42-year-old African-American male patient with metastatic disease. NCI-H460 exhibits epithelial-like morphology and adherent growth in monolayer culture. These cells have a hypotriploid karyotype, with a modal chromosome number of 57 (range 53–65), and a doubling time of approximately 23–33 hours. These cells express keratin and vimentin, indicative of both epithelial and mesenchymal phenotypes, but is negative for neurofilament triplet proteins. NCI-H460 demonstrates tumorigenic potential in nude mice models, forming subcutaneous xenografts.
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NCI-H460 serves as an in vitro and in vivo model for studying large cell lung carcinoma and for anticancer drug screening. They are particularly beneficial in 3D cell culture systems, allowing researchers to study tumor growth and evaluate therapeutic responses. The co-expression of epithelial (keratin) and mesenchymal (vimentin) markers makes this cell line valuable for studies on epithelial-mesenchymal transition (EMT) and metastasis progression. Moreover, NCI-H460 contributes to the development of targeted therapies, offering a relevant platform for testing compounds that modulate lung cancer signaling pathways.
