For research use only
| Cat No. | ABC-TC0875 |
| Product Type | Human Nerve Tumors Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Product Code | ONS76 |
ONS-76 is a medulloblastoma line from a 2-year-old girl, p53-WT, CD133⁺,NSE⁺,MHC-inducible,ideal for stem-like tumor research and neuro-oncology targeting.
The ONS-76 cell line is a human medulloblastoma cell line derived from cerebellar tumor tissue of a 2-year-old Japanese female patient. Classified as Group 3 medulloblastoma by molecular profiling, it exhibits epithelial-like morphology and grow as loosely adherent monolayers. These cells show co-expresses neural progenitor markers (SOX2, Nestin) and neuronal differentiation markers, with high proliferation and a semi-differentiated state. Genetically, ONS-76 retains wild-type TP53 by sequencing (exons 5-9) and expresses neuron-specific markers like NSE and neurofilament proteins, while lacking glial markers GFAP and S-100. Upon interferon-gamma stimulation, the cells inducibly express HLA-DR (MHC-II) but constitutively express HLA-ABC (MHC-I). ONS-76 also shows elevated VE-cadherin (CDH5) and includes CD133-positive subpopulations, suggesting stem-like traits. These cells are tumorigenic when transplanted into nude mice. ONS-76 is widely used to study medulloblastoma radioresistance, neural progenitor differentiation, and therapeutic targeting in neuro-oncology.
| Product Code | ONS76 |
| Species | Human |
| Cat.No | ABC-TC0875 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
The ONS-76 cell line is widely used as an in vitro model for studying medulloblastoma biology, particularly in pediatric brain tumor research. Its responsiveness to p53-mediated pathways makes it valuable for DNA damage response studies and anti-cancer drug screening. Additionally, due to its SHH pathway activity, ONS-76 is frequently used in investigating SHH-subgroup-specific therapeutics and signaling mechanisms. Researchers also employ this cell line in neurodevelopmental studies, given its expression of neuronal precursor markers.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
