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Tumor Cell Lines

OSCA-8

  • BSL

    2

  • 228
OSCA-8 is a canine osteosarcoma cell line derived from a left-shoulder tumor of a 1-year old intact male Rottweiler.
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Home | Tumor Cell Lines | Animal Tumor Cell Lines | OSCA-8
Product Code

OSCA-8; OSCA8; OSA8
Species

Canine
Cat.No

ABC-TC5571
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Shipping Info

Dry ice
Growth Conditions

37 ℃, 5% CO2
Biosafety Level

2
Storage

Liquid Nitrogen
Product Type

Canine Sarcoma Cell Lines

Description

Brightfield micrograph of OSCA-8, showing adherent growth, 4X magnification.
OSCA-8 is a canine osteosarcoma cell line that was originally isolated from the humerus of a 2-year-old male Rottweiler with osteosarcoma. OSCA-8 exhibits spindle-shaped morphology and adherent culture properties. This cell line is tumorigenic; it gives rise to both orthotopic and heterotopic tumor xenografts in SCID mice. The genomic profile of OSCA-8 resembles the most aggressive type of osteosarcoma. Osteosarcoma arises from primitive transformed cells of mesenchymal origin, which demonstrate osteoblastic differentiation and generate malignant osteoid.

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Application

  • The OSCA-8 cell line’s relevance lies in its application to address the challenges of canine osteosarcoma, characterized by high metastasis rates and a grim prognosis. It serves as a valuable tool to examine inhibitor cytotoxicity, elucidate resistance mechanisms against established drugs, and innovate novel therapeutic approaches to induce apoptosis. OSCA-8 contributes significantly to advancing the understanding and management of this aggressive disease in canines.

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