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Tumor Cell Lines

OVTOKO

  • BSL

    1

  • 316
Ovarian clear cell adenocarcinoma. Cells are transplantable to both mouse hypodermis and abdominal.
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Home | Tumor Cell Lines | Human Tumor Cell Lines | OVTOKO
Species

Human
Cat.No

ABC-TC0888
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Human Ovarian Cancer Cell Lines

Description

OVTOKO is a human ovarian clear cell adenocarcinoma (OCCC) cell line created from a metastatic tumor in the spleen of a woman who had previously undergone CAP (cyclophosphamide, doxorubicin, and cisplatin) chemotherapy. OVTOKO exhibits an epithelial-like morphology with adherent growth properties. These cells harbor an aneuploid karyotype, typically within the hypotriploid ranges. This cell line shows strong co-expression of cytokeratins 7/8/18/19, as well as EGFR and vimentin, reflecting both epithelial and mesenchymal traits. They are negative for tumor-associated antigens CA19-9 and CA125, which helps distinguish them from other ovarian cancer subtypes. This cell line displays aggressive tumorigenic and metastatic potential, forming peritoneal implants and distant metastases upon intraperitoneal transplantation in nude mice. These features make OVTOKO a valuable model for studying tumor progression mechanisms and therapeutic strategies.

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Citation

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Application

  • The OVTOKO cell line serves as a valuable preclinical model for studying the pathobiology of ovarian clear cell carcinoma, particularly in the context of malignant progression and chemoresistance. Originating from a patient with prior CAP chemotherapy, OVTOKO cells provide a controlled environment to study the molecular mechanisms of drug resistance, tumor adaptation, and therapeutic response in resistant ovarian cancer. Its unique phenotypic and molecular characteristics make it an indispensable tool for identifying potential therapeutic targets aimed at overcoming resistance and improving clinical outcomes in patients with ovarian clear cell carcinoma.

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