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Tumor Cell Lines

OVTOKO

  • BSL

    1

  • 288
Ovarian clear cell adenocarcinoma. Cells are transplantable to both mouse hypodermis and abdominal.
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Species

Human

Cat.No

ABC-TC0888

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Spleen

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Ovarian Cancer Cell Lines

Description

OVTOKOOVTOKO is a human ovarian clear cell adenocarcinoma (OCCC) cell line created from a metastatic tumor in the spleen of a woman who had previously undergone CAP (cyclophosphamide, doxorubicin, and cisplatin) chemotherapy. OVTOKO exhibits an epithelial-like morphology with adherent growth properties. These cells harbor an aneuploid karyotype, typically within the hypotriploid ranges. This cell line shows strong co-expression of cytokeratins 7/8/18/19, as well as EGFR and vimentin, reflecting both epithelial and mesenchymal traits. They are negative for tumor-associated antigens CA19-9 and CA125, which helps distinguish them from other ovarian cancer subtypes. This cell line displays aggressive tumorigenic and metastatic potential, forming peritoneal implants and distant metastases upon intraperitoneal transplantation in nude mice. These features make OVTOKO a valuable model for studying tumor progression mechanisms and therapeutic strategies.

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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • The OVTOKO cell line serves as a valuable preclinical model for studying the pathobiology of ovarian clear cell carcinoma, particularly in the context of malignant progression and chemoresistance. Originating from a patient with prior CAP chemotherapy, OVTOKO cells provide a controlled environment to study the molecular mechanisms of drug resistance, tumor adaptation, and therapeutic response in resistant ovarian cancer. Its unique phenotypic and molecular characteristics make it an indispensable tool for identifying potential therapeutic targets aimed at overcoming resistance and improving clinical outcomes in patients with ovarian clear cell carcinoma.

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