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1 vial

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PL-21 cells are a human myeloid cell line originating from a 24-year-old man with refractory acute promyelocytic leukemia following mediastinal granulocytic sarcoma. These cells exhibit myeloid characteristics, displaying an immature morphology with azurophilic granules. Their identity as monocytes is confirmed through the expression of surface markers CD14/CD68 and the presence of monocyte-specific esterase. While they may appear monocytic, these cells can be induced to differentiate into other myeloid lineages using phorbol ester. Notably, PL-21 cells carry an FLT3 internal tandem duplication. To maintain these cells, subculturing at a ratio of 1:2 to 1:3 every 3-4 days is recommended.


Why choose PL-21 from AcceGen?

PL-21 cell line from AcceGen boasts high viability and is provided in a sterile condition, rigorously tested to be free from bacteria, fungi, and mycoplasma through PCR-based assays, with no virus genome fragments detected via qPCR. Its identity is confirmed through STR analysis, ensuring reliability and authenticity for research purposes.

Source Organ

Peripheral Blood

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The PL-21 cell line holds significant promise for various applications in the field of leukemia research. As a myeloid cell line, it offers valuable material for investigating the proliferation and differentiation mechanisms of human leukemia cells. Additionally, PL-21 serves as an excellent model for in-depth studies focused on key oncogenic factors like p53, FLT3, and KRAS within the context of leukemia, offering critical insights into the molecular underpinnings of this disease and potential avenues for therapeutic intervention.

Growth Conditions

37 ℃, 5% CO2

Product Type

Human Leukemia Cell Lines

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