Explore Products
Tumor Cell Lines

THP-1

  • BSL

    1

  • 275
The cells are phagocytic (for both latex beads and sensitized erythrocytes) and lack surface and cytoplasmic immunoglobulin. Monocytic differentiation can be induced with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).
Request Your Custom Quote Today

Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.

Get a Quote
  • High Purity Levels
  • Precision and Reliability
  • Customization Options
Product Code

THP1; THP 1; THPI

Species

Human

Cat.No

ABC-TC1234

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Monocyte

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Peripheral Blood

Disease

Acute Myeloid Leukemia

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Leukemia Cell Lines

Description

THP-1TTHP-1 is a human monocytic leukemia-derived tumor cell line originating from the peripheral blood of a 1-year-old male Caucasian patient diagnosed with acute monocytic leukemia. These cells grow in suspension with a round morphology and have typical monocyte features. They possess Fc and C3b receptors, but lack surface or cytoplasmic immunoglobulins. THP-1 cells show positive α-naphthyl butyrate esterase activity inhibited by NaF, and display phagocytic activity for latex beads and opsonized sheep erythrocytes. They can also restore T-lymphocyte response to Concanavalin A (Con A) and produce lysozyme, confirming their monocyte lineage. The cell line’s HLA haplotypes include HLA-A2, -A9, -B5, -DRW1, and -DRW2. Karyotype analysis reveals a near-diploid chromosomal pattern with multiple structural abnormalities, consistent with leukemic origin. THP-1 is often used in NLRP3 inflammasome and NF-κB pathway studies due to high expression of associated components. The cells are tumorigenic, and non-metastatic in immunodeficient mice.

View Product Image

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • THP-1 cells find diverse applications due to their unique characteristics. They are widely used for transfection, enabling gene manipulation and functional studies. Additionally, these cells offer valuable insights into monocyte biology and immune responses, providing a reliable model to study monocyte-to-macrophage differentiation. Moreover, THP-1 cells prove invaluable in assessing immune-modulatory effects of compounds in both resting and activated states, making them essential in drug development and immunological research.

Inquiring THP-1

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

AcceGen Scroll Top Button