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| Product Code | THP1; THP 1; THPI |
| Species | Human |
| Cat.No | ABC-TC1234 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Monocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Myeloid Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
TTHP-1 is a human monocytic leukemia-derived tumor cell line originating from the peripheral blood of a 1-year-old male Caucasian patient diagnosed with acute monocytic leukemia. These cells grow in suspension with a round morphology and have typical monocyte features. They possess Fc and C3b receptors, but lack surface or cytoplasmic immunoglobulins. THP-1 cells show positive α-naphthyl butyrate esterase activity inhibited by NaF, and display phagocytic activity for latex beads and opsonized sheep erythrocytes. They can also restore T-lymphocyte response to Concanavalin A (Con A) and produce lysozyme, confirming their monocyte lineage. The cell line’s HLA haplotypes include HLA-A2, -A9, -B5, -DRW1, and -DRW2. Karyotype analysis reveals a near-diploid chromosomal pattern with multiple structural abnormalities, consistent with leukemic origin. THP-1 is often used in NLRP3 inflammasome and NF-κB pathway studies due to high expression of associated components. The cells are tumorigenic, and non-metastatic in immunodeficient mice.
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THP-1 cells find diverse applications due to their unique characteristics. They are widely used for transfection, enabling gene manipulation and functional studies. Additionally, these cells offer valuable insights into monocyte biology and immune responses, providing a reliable model to study monocyte-to-macrophage differentiation. Moreover, THP-1 cells prove invaluable in assessing immune-modulatory effects of compounds in both resting and activated states, making them essential in drug development and immunological research.
