For research use only
| Cat No. | ABC-TC0725 |
| Product Type | Human Leukemia Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Leukemia |
| Product Code | NB4; NB.4 |
NB-4 leukemia cells carry t(15;17) PML-RARα, grow in suspension,RA-sensitive,hypertriploid,and ideal for studying APL differentiation and therapy response.
The NB-4 cell line is a human acute promyelocytic leukemia (APL) cell line established from the bone marrow of a patient experiencing the second relapse of acute promyelocytic leukemia. These cells exhibit a myeloblastic morphology with large nuclei and prominent nucleoli and grow in suspension culture. NB-4 cells harbor the t(15;17)(q24;q21) chromosomal translocation, resulting in the PML-RARA fusion gene, a hallmark of APL. This fusion gene blocks normal myeloid differentiation, making NB-4 an ideal model to study differentiation therapy. Immunophenotypically, NB-4 cells express granulocytic markers, as well as T-cell markers CD2 and CD4, and the monocytic marker CD9. Upon treatment with retinoic acid, NB-4 cells undergo rapid morphological and functional maturation, making them a valuable model for studying the effects of retinoic acid on hematopoietic proliferation and differentiation.
| Product Code | NB4; NB.4 |
| Species | Human |
| Cat.No | ABC-TC0725 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
The NB-4 cell line is a key model for studying the t(15;17) chromosomal translocation and retinoic acid (RA)-induced differentiation into polynuclear cells. It enables investigation of RA-regulated gene expression involved in hematopoietic proliferation and differentiation. Additionally, NB-4 cells facilitate evaluation of maturation inducers, growth factors, chemotherapeutics, and retroviral vectors, broadening insights into their effects on cellular function.
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