Porcine Coronary Endothelial Cells

Description

Porcine Coronary Artery Endothelial Cells (PCAEC) are primary endothelial cells derived from healthy porcine coronary arteries and cryopreserved post-isolation to preserve native function. These cells exhibit classic cobblestone morphology and form confluent, contact-inhibited monolayers in vitro, reflecting fundamental features of coronary endothelial cell biology. PCAEC express endothelial-specific markers such as CD31, von Willebrand factor (vWF), and VE-cadherin, which are commonly used endothelial cell markers in porcine models and support their essential role in maintaining vascular integrity. Functionally, these cells regulate hemostasis, vascular tone, and leukocyte trafficking, and also participate in endothelial repair processes relevant to endothelial cell regeneration under physiological and pathological conditions. Owing to the close physiological similarity between porcine and human vasculature, PCAEC are widely applied in pig cardiovascular research, including in vitro models of endothelial dysfunction, vascular inflammation, atherosclerosis, and cardiovascular drug testing. To maintain optimal performance and functional consistency, repeated freeze–thaw cycles should be avoided.