Porcine Coronary Endothelial Cells

PCAECs have become indispensable in cardiovascular research. They enable detailed exploration of obesity-associated vascular dysfunction, particularly how resistin impairs endothelial function via oxidative stress and NO synthase suppression. These cells have also an advanced understanding of endothelial relaxation, with studies showing that secretoneurin promotes NO synthase expression. Additionally, PCAECs were pivotal in evaluating the anti-inflammatory and cardioprotective effects of adenosine-lidocaine drug combinations, demonstrating their role in endothelial adhesion and immune modulation.