Rabbit Dermal Papilla Cells

Description

Rabbit Dermal Papilla Cells (rDPCs) are specialized mesenchymal cells isolated from the dermal papilla at the base of hair follicles in rabbit skin. Following primary culture, these cells are cryopreserved. rDPCs typically exhibit spindle-shaped morphology and form characteristic aggregates in culture, reflecting their critical role in hair follicle development and cycling. They express key markers including alkaline phosphatase (ALP), versican, and CD133, which indicate their inductive potential in regulating hair growth and folliculogenesis. These cells secrete important signaling molecules such as Wnt, BMP, and FGF, which mediate epithelial-mesenchymal interactions essential for hair follicle stem cell activity. Rabbit dermal papilla cells are valuable models for studying hair regeneration, alopecia, and skin tissue engineering. In vitro, these cells do not proliferate or undergo passaging, and repeated freezing and thawing should be avoided to maintain viability and function. Although distinct from general rabbit cells, rDPCs represent a highly specialized follicular mesenchymal population with unique inductive capability.