Rat Cardiac Microvascular Endothelial Cells (RCMECs) are primary cells isolated from the heart tissue of rats, exhibiting a flat, cobblestone-like morphology characteristic of epithelial monolayer. RCMECs play a critical role in maintaining vascular homeostasis by regulating blood pressure, vascular tone, and thrombosis prevention through paracrine signaling. They serve as mediators in pathogenesis of various cardiovascular diseases, including myocardial ischemia-reperfusion injury and diabetic cardiomyopathy. RCMECs show high expression of endothelial markers such as CD31, α-SMA, von Willebrand factor (vWF), and Factor VIII. 
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