Description
IL-10 (interleukin 10), also known as IL10, is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
| Species |
Human
|
| Cat.No |
ABC-GF0013
|
| Product Category |
Cell Culture Media, Kits & Reagents |
| Size/Quantity |
20 µg/100 µg/1 mg
|
| Shipping Info |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
|
| Storage |
-20°C
|
| Product Type |
Others
|
| Concentration |
≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
|
| Buffer Mix |
Supplied as sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
|
| Key Features |
< 20 EU per mg protein
|
| Quality Control |
HPLC-verified.
|
