Recombinant Human IL-15 Protein

Description

The protein encoded by the IL-15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and interleukin 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other’s activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. The IL-15 would induce the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that IL-15 may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.