Recombinant Mouse BDNF Protein (His Tag)

Description

Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, it is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. BDNF is expressed in cortical neurons and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the central nervous system (CNS). The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.