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| Species | Human |
| Cat.No | ABL-TC0611 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Tongue |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Tongue Cancer Cell Lines |
The SAS cell line is a well-established cell line derived from a human tongue squamous cell carcinoma. It was initially isolated from the primary tumor of a patient with tongue cancer. These cells are commonly used in cancer research, particularly in studies related to oral squamous cell carcinoma (OSCC) and head and neck cancer.
SAS cells exhibit characteristics typical of cancer cells, including uncontrolled proliferation, resistance to apoptosis (programmed cell death), and the ability to form tumors in animal models when injected subcutaneously. Researchers use SAS cells to investigate various aspects of cancer biology, including tumor progression, metastasis, drug sensitivity, and molecular mechanisms underlying oncogenesis.
Studies utilizing the SAS cell line have contributed significantly to our understanding of the molecular pathways involved in oral cancer development and progression. Additionally, SAS cells serve as a valuable tool for evaluating potential therapeutic agents, such as chemotherapeutic drugs, targeted therapies, and immunotherapies, aimed at treating oral cancer.
Why choose SAS from AcceGen?
At AcceGen, we present SAS – a cutting-edge cell line meticulously crafted for your biomedical research demands. SAS stands as a symbol of our commitment to excellence, offering a product that undergoes stringent Quality Control (QC) tests to ensure reliability and precision in your experiments.
Rigorous Quality Control
We understand the significance of reliable research outcomes, and SAS reflects our dedication to quality. The following comprehensive QC tests are conducted
Sterility Assurance
Thorough testing for bacterial, fungal, and Mycoplasma contamination, utilizing advanced Polymerase Chain Reaction (PCR) technology.
Stringent measures are taken to guarantee the absence of human pathogens, providing a sterile and safe environment for your experiments.
Viability Excellence
Post-thaw viability surpassing 95%, ensuring the health and robustness of SAS cells for consistent and reproducible results.
Identity Verification
Utilization of Short Tandem Repeat (STR) analysis featuring 16 probes (15 STR loci plus Amelogenin) for precise identity confirmation and purity assessment.
Growth Integrity
Assessment of cell growth based on detailed examinations of morphology and immunocytochemistry targeting multiple undifferentiation markers, ensuring the reliability of SAS in various experimental setups.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
Here are some key applications:
Cancer Biology Research
Investigate the fundamental aspects of tongue cancer biology, including tumor growth, invasion, metastasis, and response to therapeutic interventions.
Therapeutic Efficacy Studies
Assess the anti-tumor activity and therapeutic responses of the SAS xenograft model to various treatments, such as platinum-based chemotherapeutic agents, taxanes, and valproic acid.
Drug Development and Screening
Utilize the SAS cell line and xenograft model as preclinical tools for testing the efficacy of potential anti-cancer drugs and novel therapeutic compounds.
In Vivo Tumor Behavior Studies
Understand the in vivo behavior of tongue cancer through the SAS xenograft model, providing insights into tumor growth patterns, response to treatment, and interactions with the microenvironment.
CDX (Cell Line Derived Xenograft) Model Development
Generate SAS xenograft mouse models to study the behavior of tongue cancer cells in a complex in vivo setting, enabling researchers to observe tumor development and response to interventions.
Mechanistic Studies
Explore the molecular mechanisms underlying tongue cancer progression, invasion, and metastasis using the SAS cell line and xenograft model.
Translational Research
Bridge the gap between basic research findings and clinical applications by using the SAS xenograft model to simulate human tumor responses and therapeutic outcomes.
Immunotherapy Research
Investigate the potential of immunotherapeutic approaches in treating tongue cancer using the SAS cell line and xenograft model.
