STING Knockout IRF-inducible Lucia Luciferase Reporter Raw264.7 Cell Line

Description

STING Knockout IRF-inducible Lucia Luciferase Reporter Raw264.7 Cell Line is a genetically engineered macrophage model derived from murine Raw264.7 cells, featuring STING (Stimulator of Interferon Genes) gene knockout and an IRF (Interferon Regulatory Factor)-responsive Lucia luciferase reporter system. This cell line maintains its monocyte/macrophage origin with characteristic adherent morphology while enabling specific study of STING-independent IRF signaling pathways. The integrated IRF-inducible Lucia luciferase reporter allows sensitive, quantitative monitoring of IRF pathway activation through bioluminescent detection, making it particularly valuable for research in innate immunity and interferon signaling. Key macrophage markers including CD14 and F4/80 are retained, with the STING knockout eliminating cross-talk from cGAS-STING pathway activation. The Lucia luciferase reporter provides enhanced stability and sensitivity compared to conventional luciferase systems. Cells are maintained at low passage numbers (<P20) to ensure genetic stability. The cells have undergone rigorous quality control testing and are confirmed free of contamination from mycoplasma, fungi, yeast, and bacteria.