For research use only
| Cat No. | ABC-TC612S |
| Product Type | Human Sarcoma Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
TE-671 is a rhabdomyosarcoma line expressing MyoD, NSE, and nAChR, useful for studying ARMS pathology and neuromuscular tumor characteristics.
TE-671 is a human rhabdomyosarcoma (RMS) cell line originally derived from a biopsy of a chest wall tumor in a 6-year-old female patient. Although initially classified as a medulloblastoma, further analysis confirmed its origin as alveolar-type rhabdomyosarcoma, a rare and aggressive soft tissue sarcoma. TE-671 cells exhibit a polygonal to spindle-shaped morphology and grow adherently in culture. Cytogenetically, these cells carry complex karyotypic abnormalities, including translocations affecting PAX3 and FOXO1 genes, which are common oncogenic drivers in alveolar rhabdomyosarcoma. TE-671 expresses muscle differentiation markers such as desmin, myogenin, and MyoD1, as well as nicotinic acetylcholine receptors (nAChRs), making them suitable for neuropharmacological studies. TE-671 are often distinguished from the similarly referenced RD cell line in comparative rhabdomyosarcoma research due to differences in fusion status and molecular phenotype.
| Species | Human |
| Cat.No | ABC-TC612S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Sarcoma Cell Lines |
TE-671 cells are widely used in rhabdomyosarcoma biology, myogenic differentiation studies, and neuromuscular pharmacology due to their expression of nAChRs. They are also employed in preclinical drug screening, muscle tumor modeling, and evaluation of sarcoma-specific gene fusions. TE-671 cells exhibit voltage-gated sodium currents and show expression of the NaV1. 7 channel, making them a useful in vitro model for studying voltage-gated sodium channels (VGSCs), particularly in the context of pain-related research.
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