| Species |
Human
|
| Cat.No |
ABC-RC049Y
|
| Quality Control |
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
|
| Product Category |
Transfected Stable Cell Lines |
| Size/Quantity |
1 vial
|
| Cell Type |
Monocyte
|
| Shipping Info |
Dry Ice
|
| Growth Conditions |
37 ℃, 5% CO2
|
| Source Organ |
Peripheral Blood
|
| Disease |
Acute Monocytic Leukemia
|
| Biosafety Level |
1
|
| Storage |
Liquid Nitrogen
|
| Product Type |
Reporter Stable Cell Lines
|
| Host Cell |
THP-1
|
| Gene Info |
STAT3 / Luciferase
|
Description
THP-1/STAT3 Reporter (Luc) Stable Cell Line is a genetically engineered human monocytic cell line designed to monitor STAT3 (Signal Transducer and Activator of Transcription 3) signaling activity through luciferase (Luc) reporter expression. Derived from THP-1 cells, the cell line maintains key native THP-1 characteristics, such as the capacity to upregulate CD14 upon differentiation and PMA-induced differentiation into macrophage-like cells, while featuring a luciferase reporter system under the control of STAT3-responsive elements. The cell line enables sensitive quantification of STAT3 pathway activation through bioluminescence measurement, making it particularly valuable for studying inflammatory responses, immune regulation, and oncogenic signaling research. Cells exhibit dose-dependent luciferase activity upon STAT3 activation while retaining their original biological properties, allowing for high-throughput screening applications and kinetic studies of STAT3 signaling dynamics. Maintained at low passage numbers (<P20) to ensure reporter stability and consistent performance, this cell line provides a reliable tool for immunology and cancer research. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, Fungi, Yeast and Bacteria.
