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TNFRSF1B Knockout Cell Lysate

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis […]
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Home | Transfected Stable Cell Lines | Knockout Cell Lysate | TNFRSF1B Knockout Cell Lysate
Species

Human
Cat.No

ABC-KC2132
Product Category Transfected Stable Cell Lines
Size/Quantity

100ug
Shipping Info

Ice Pack
Growth Conditions

37 ℃, 5% CO2
Storage

Store TNFRSF1B KO Cell Lysate At -20℃. Please Avoid Repeated Freeze-Thaw Cycles.
Product Type

CRISPR Knockout Cell Lysate
Host Cell

HeLa

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

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