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Xpress™ Human AXL Over-expressing Cell Line (MOLM-13)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human AXL Over-expressing Cell Line (MOLM-13)
Species

Human
Cat.No

ABC-X0245C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphoblast-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Blood
Disease

Acute Myeloid Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MOLM-13

Description

AXL MOLM-13 Overexpression Cell Line is a genetically engineered model derived from the MOLM-13 acute myeloid leukemia cell line, tailored to customer requirements. AXL MOLM-13 overexpression cell line is generated by stable integration of exogenous human AXL into host cells via optimized lentiviral transduction. Overexpression clone is validated at gene level by qRT-PCR.
Target
The AXL gene encodes a receptor tyrosine kinase involved in cell survival, proliferation, and immune modulation via the PI3K/AKT and MAPK pathways. Its overexpression is associated with therapy resistance and poor prognosis in leukemia, non-small cell lung cancer, and breast cancer. AXL is a critical mediator of epithelial-to-mesenchymal transition and immune evasion. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model facilitates studies on AXL-driven oncogenic signaling in myeloid malignancies, offering a tool for evaluating AXL-targeted inhibitors and antibody therapies. It supports drug screening and mechanistic analysis of leukemic cell proliferation and immune checkpoint regulation.

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