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Xpress™ Human CD39 Over-expressing Cell Line (CT26)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human CD39 Over-expressing Cell Line (CT26)
Species

Human
Cat.No

ABC-X0137C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Colon
Disease

Colorectal Carcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CT26

Description

Xpress™ Human CD39 over-expressing cell line (CT26) is a genetically engineered model derived from selected murine CT26 parental cell line based on customers’ requirement. Human CD39 overexpression cell line is generated by stable integration of exogenous human CD39 gene into CT26 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
CD39 (ENTPD1) is an ectonucleotidase that hydrolyzes extracellular ATP and ADP into AMP, contributing to the immunosuppressive adenosine pathway. It is widely expressed in the tumor microenvironment and associated with regulatory T cell function, immune tolerance, and poor cancer prognosis. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The Xpress™ Human CD39 over-expressing cell line (CT26) is a suitable model for investigating adenosine-mediated immunosuppression and for screening CD39 inhibitors. It is widely used in the development of cancer immunotherapy and metabolic pathway modulators.

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